OBJECTIVES: The distribution of left ventricular (LV) fibrosis and the percent fibrosis in patients with dilated cardiomyopathy (DCM) were evaluated using late gadolinium enhanced (LGE) MRI. Then the relation with the LV ejection fraction (EF) and deceleration time (DT), an index of diastolic function obtained using echocardiography, was investigated.
METHODS: LGEMRI at 20 min after intravenous injection of Gd-DTPA (0.15 +/-0.03 mmol/kg) was performed in 17 patients with DCM. The distribution of the LV enhanced area and LGE rate (%) were calculated. EF, as well as E/A ratio and DT were obtained using echocardiography.
RESULTS: LGE was observed in 15 out of 17 patients (88%) and the enhanced region appeared to represent myocardial fibrosis. The LV fibrosis was often found in the intraventricular septum (IVS), but there were no differences in its distribution. The LGE rate (%) had a correlation between cardiac magnetic resonance ejection fraction (CMREF) (Y = 51.7 – 2.1X [R(2) = 0.23, P<0.001]) and DT (Y = 162.2 +12.0X [R(2) = 0.35, P<0.001]).
CONCLUSIONS: The LV fibrosis is often found in the IVS with DCM. A correlation exists between LGE rate (%) to EF on CMR and DT on echocardiography in patients with DCM.
Cardiopulmonary Imaging, Section Head
Cleveland Clinic Florida
Latest posts by Jacobo Kirsch (see all)
- Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized, Controlled Trial - June 15, 2015
- Myocardial Fibrosis on Cardiac Magnetic Resonance and Cardiac Outcomes in Hypertrophic Cardiomyopathy: A Meta-Analysis - June 9, 2015
- Performance of CMR Methods for Differentiating Acute From Chronic MI - June 9, 2015