Cardiac Magnetic Resonance Imaging Characteristics of Isolated Left Ventricular Noncompaction in a Chinese Adult Han Population

OBJECTIVES: To analyze cardiac magnetic resonance imaging (CMR) characteristics in patients with isolated left ventricular noncompaction (IVNC) and assess its value in the diagnosis of IVNC in a Chinese adult Han population.

METHODS: We collected a consecutive series of 30 patients with IVNC from January 1, 2007, to December 31, 2008. During the same period, we prospectively included patients drawn from groups given a potential differential diagnosis for IVNC. All magnetic resonance images were analyzed using 17-segment model.

RESULTS: Left ventricular ejection fraction was significantly lower for patients with DCM (16.2 ± 5.2%, P < 0.001) and higher in AR (47.6 ± 16.2%, P = 0.009), AS (54.6 ± 21.1%, P = 0.001) and HHD (62.4 ± 6.8%, P < 0.001) compared with IVNC (33.0 ± 14.1%). The two-layered structure was most frequently seen at the apical segments, followed by the mid-cavity and basal segments in patients with INVC. The anterior and lateral walls were more commonly involved in patients with IVNC. The number of noncompacted segments and end-diastolic ratio of non-compacted to compacted myocardium (NC/C ratio) was greater in patients with IVNC than in other five groups. The end-diastolic NC/C ratio of >2.5 had 96.4% sensitivity and 97.4% specificity for identifying patients with IVNC.

CONCLUSIONS: CMR provides an accurate and reliable evaluation of the localization and extent of noncompacted myocardium at end-diastole. The end-diastolic NC/C ratio of >2.5 had high diagnostic accuracy for IVNC in a Chinese adult Han population.

PMID: 21046254

Posted in Magnetic Resonance Imaging and tagged , , , .


  1. See also:

    Comparison of clinical and MRI features between dilated cardiomyopathy and left ventricular noncompaction
    Yu JC, Zhao SH, Jiang SL, Wang LM, Wang ZF, Lu MJ, Ling J, Zhang Y, Yan CW, Liu Q, Cheng HB.
    Zhonghua Xin Xue Guan Bing Za Zhi. 2010 May;38(5):392-7.
    PMID: 20654095

  2. See also:

    Diagnosis of left-ventricular non-compaction in patients with left-ventricular systolic dysfunction: time for a reappraisal of diagnostic criteria?
    Kohli SK, Pantazis AA, Shah JS, Adeyemi B, Jackson G, McKenna WJ, Sharma S, Elliott PM.
    Eur Heart J. 2008 Jan;29(1):89-95. Epub 2007 Nov 9.
    PMID: 17993472

  3. Many case reports and few series keep appearing on this type of cardiomyopathy. An interesting study on ECG changes in a large cohort of IVNC patients showed that normal ECG findings were found only in 24.6% of the patients. Most of the ECG abnormalities, however, were non-specific: ST-T changes in 35.2% and bundle branch block in 14.9%. Notably, Brugada-like ECG was frequently seen (3.2%).

    What I found very interesting was that the incidence of the ECG findings was not dependent upon the extent of non-compaction.

    Electrocardiography characteristics of isolated non-compaction of ventricular myocardium in Japanese adult patients. Shoji M, Yamashita T, Uejima T, Asada K, Semba H, Otsuka T, Sagara K, Sawada H, Isobe M, Aizawa T.
    Circ J. 2010;74(7):1431-5.
    [Free access]

  4. See also:

    Measurement of trabeculated left ventricular mass using cardiac magnetic resonance imaging in the diagnosis of left ventricular non-compaction.
    Jacquier A, Thuny F, Jop B, Giorgi R, Cohen F, Gaubert JY, Vidal V, Bartoli JM, Habib G, Moulin G.
    Eur Heart J. 2010 May;31(9):1098-104. Epub 2010 Jan 19.
    PMID: 20089517

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