Accuracy of Coronary CT Angiography Using a Submillisievert Fraction of Radiation Exposure Comparison With Invasive Coronary Angiography

OBJECTIVES: Coronary computed tomography angiography (CTA) is increasingly being used for evaluation of coronary artery disease (CAD). As a result of the widely reported potential of carcinogenic risk from x-ray based examinations, many strategies have been developed for dose reduction with CTA. The purpose of this study was to assess the diagnostic accuracy of CTA acquired with a submillisievert fraction of effective radiation dose reconstructed with a model-based iterative reconstruction (MBIR) using invasive coronary angiography (ICA) as a standard of reference.

METHODS: In 36 patients (body mass index range 17 to 39 kg/m2) undergoing ICA for CAD evaluation, a CTA was acquired using very low tube voltage (80 to 100 kV) and current (150 to 210 mA) and was reconstructed with MBIR. CAD (defined as ≥50% luminal narrowing) was assessed on CTA and on ICA.

RESULTS: CTA resulted in an estimated radiation dose exposure of 0.29 ± 0.12 mSv (range 0.16 to 0.53 mSv), yielding 96.9% (436 of 450) interpretable segments. On an intention-to-diagnose basis, no segment was excluded, and vessels with at least 1 nonevaluable segment and no further finding were classified as false positive. This resulted in a sensitivity, specificity, positive, and negative predictive value and accuracy of 100%, 74%, 77%, 100%, and 86% per patient and 85%, 86%, 56%, 96%, and 85% per vessel, respectively.

CONCLUSIONS: The use of MBIR reconstruction allows accurate noninvasive diagnosis of CAD with CTA at a submillisievert fraction of effective radiation dose comparable with a chest x-ray in 2 views. 


Posted in Computed Tomography and tagged , , , , .


  1. Did the authors examine the impact on identification of wall changes/plaque or ‘only’ luminal stenosis?

    Did the authors in this context examine the impact on ‘low contrast resolution’?

    Contrast-to-noise ratio and low-contrast object resolution on full- and low-dose MDCT: SAFIRE versus filtered back projection in a low-contrast object phantom and in the liver.
    Baker ME, Dong F, Primak A, Obuchowski NA, Einstein D, Gandhi N, Herts BR, Purysko A, Remer E, Vachhani N.
    AJR Am J Roentgenol. 2012 Jul;199(1):8-18.
    PMID: 22733888.

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