Aortic Pulse Wave Velocity Is Associated With Measures of Subclinical Target Organ Damage

OBJECTIVES: Our goal was to evaluate the associations of central arterial stiffness, measured by aortic pulse damage in the coronary, peripheral arterial, cerebral, and renal arterial beds. Arterial stiffness is associated with adverse cardiovascular outcomes. We hypothesized that aPWV is associated with subclinical measures of atherosclerosis—coronary artery calcification(CAC) and ankle-brachial index (ABI) and arteriolosclerosis—brain white matter hyperintensity (WMH) and urine albumin-creatinine ratio (UACR).

METHODS: Participants (n = 812; mean age 58 years; 58% women, 71% hypertensive) belonged to hypertensive sibships and had no history of myocardial infarction or stroke. aPWV was measured by applanation tonometry, CAC by electron beam computed tomography, ABI using a standard protocol, WMH volume by brain magnetic resonance, and UACR by standard methods. WMH was log-transformed, whereas CAC and UACR were log-transformed after adding 1 to reduce skewness. The associations of aPWV with CAC, ABI, WMH, and UACR wer Germain Ifedi Womens Jersey


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  1. Important work, shedding light on the pathophysiology of aortic stifness and its potential effect on adverse outcomes.

  2. Agree with Dr. Rubinshtein.

    What I found of most interest is that the authors did NOT find an association between aPWW and subclinical target organ damage to the renal arterial beds (a finding that other authors had reported previously). The rational given in the discussion to explain this ‘disagreement’ is very well explained and in my mind may give insight in how to better protect the renal function in the hypertensive patient.

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