Are Air Pollution and Traffic Noise Independently Associated With Atherosclerosis: The Heinz Nixdorf Recall Study

OBJECTIVES: Living close to high traffic has been linked to subclinical atherosclerosis, however it is not clear, whether fine particulate matter (PM) air pollution or noise, two important traffic-related exposures, are responsible for the association. We investigate the independent associations of long-term exposure to fine PM and road traffic noise with thoracic aortic calcification (TAC), a reliable measure of subclinical atherosclerosis.

METHODS: We used baseline data (2000-2003) from the German Heinz Nixdorf Recall Study, a population-based cohort of 4814 randomly selected participants. We assessed residential long-term exposure to PM with a chemistry transport model, and to road traffic noise using façade levels from noise models as weighted 24 h mean noise (Lden) and night-time noise (Lnight). Thoracic aortic calcification was quantified from non-contrast enhanced electron beam computed tomography. We used multiple linear regression to estimate associations of environmental exposures with ln(TAC+1), adjusting for each other, individual, and neighborhood characteristics.

RESULTS: In 4238 participants (mean age 60 years, 49.9% male), PM2.5 (aerodynamic diameter ≤2.5 µm) and Lnight are both associated with an increasing TAC-burden of 18.1% (95% CI: 6.6; 30.9%) per 2.4 µg/m3 PM2.5 and 3.9% (95% CI 0.0; 8.0%) per 5dB(A) Lnight, respectively, in the full model and after mutual adjustment. We did not observe effect measure modification of the PM2.5 association by Lnight or vice versa.

CONCLUSIONS: Long-term exposure to fine PM and night-time traffic noise are both independently associated with subclinical atherosclerosis and may both contribute to the association of traffic proximity with atherosclerosis. Chris Herndon Jersey

PMID: 24194529

Posted in Computed Tomography, Health Policy and tagged , , , , , , .

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  1. Also Check:

    Urban Particulate Matter Air Pollution is Associated With Subclinical Atherosclerosis: Results from the HNR (Heinz Nixdorf Recall) Study.
    Bauer M, Moebus S, Möhlenkamp S, Dragano N, Nonnemacher M, Fuchsluger M, Kessler C, Jakobs H, Memmesheimer M, Erbel R, Jöckel KH, Hoffmann B; HNR Study Investigative Group.
    J Am Coll Cardiol. 2010; 56(22):1803-1808.
    https://www.thepreparedminds.com/archives/2679

    And

    Size-fractionated particle number concentrations and daily mortality in a chinese city.
    Meng X, Ma Y, Chen R, Zhou Z, Chen B, Kan H.
    Environ Health Perspect. 2013 Oct;121(10):1174-1178.
    PMID: 23942310.
    http://www.ncbi.nlm.nih.gov/pubmed/?term=Meng+X%2C+Ma+Y%2C+Chen+R%2C+Zhou+Z%2C+Chen+B%2C+Kan+H.+Size-fractionated+particle+number+concentrations+and+daily+mortality+in+a+Chinese+city.+Environ+Health+Perspect.+2013+Oct%3B121(10)%3A1174-8

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