Assessment of Coronary Plaque Characteristics by Optical Coherence Tomography in Patients With Diabetes Mellitus Complicated With Unstable Angina Pectoris


PMID: 20951380

Posted in Invasive Imaging and tagged , , , , , , .


  1. Please also read:

    Clinical Research

    Different Patterns of Vascular Response Between Patients With or Without Diabetes Mellitus After Drug-Eluting Stent Implantation: Optical Coherence Tomographic Analysis.
    Nobuyoshi Tanaka, Mitsuyasu Terashima, Sudhir Rathore, Tsuyoshi Itoh, Maoto Habara, Kenya Nasu, Masashi Kimura, Tatsuya Itoh, Yoshihisa Kinoshita, Mariko Ehara, Etsuo Tsuchikane, Keiko Asakura, Yasushi Asakura, Osamu Katoh, Takahiko Suzuki

    Objectives: We performed this study to investigate with optical coherence tomography (OCT) the vascular response after sirolimus-eluting stent (SES) implantation between patients with and those without diabetes mellitus (DM).

    Background: The difference in vascular response after SES implantation between patients with and those without DM has not been fully evaluated with OCT.

    Methods: Optical coherence tomography was performed to examine 74 nonrestenotic SES implanted in 63 patients (32 with DM and 31 without DM) at 9 months after SES implantation. For struts showing neointimal coverage, the neointimal thickness on the luminal side of each strut section was measured, and neointimal characteristics were classified into high, low, and layered signal pattern.

    Results: Baseline patient characteristics and lesion and procedural characteristics data were similar between the 2 groups. In total, 11,422 struts were analyzed. High signal neointima was observed in 90.2 ± 13.9%, low signal neointima in 7.3 ± 10.0%, and layered neointima in 2.7 ± 5.8%/stents. There was higher incidence of low signal neointima (10.5 ± 10.3% vs. 4.5 ± 5.6%, p = 0.003), neointimal thickness was larger (median: 106.8 µm, interquartile range: 79.3 to 130.4 µm vs. median: 83.5 µm, interquartile range: 62.3 to 89.3 µm; p < 0.0001), and neointimal coverage of stent struts was higher (92.1 ± 6.2% vs. 87.2 ± 11.9%; p = 0.03) in DM patients.

    Conclusions: High signal neointimal pattern was predominantly observed, and low or layered signal pattern was observed in some cases. In DM patients, low signal neointima was observed with high frequency. Neointimal coverage and neointimal thickness was also higher in DM patients as compared with non-DM patients.

  2. There is also related IVUS literature e.g.:

    Diabetes duration is associated with increased thin-cap fibroatheroma detected by intravascular ultrasound with virtual histology.
    Lindsey JB, House JA, Kennedy KF, Marso SP.
    Circ Cardiovasc Interv. 2009 Dec;2(6):543-8.

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