Cardiac PET/CT for the Evaluation of Known or Suspected Coronary Artery Disease

Positron emission tomography (PET) is increasingly being applied in the evaluation of myocardial perfusion. Cardiac PET can be performed with an increasing variety of cyclotron- and generator-produced radiotracers. Compared with single photon emission computed tomography, PET offers lower radiation exposure, fewer artifacts, improved spatial resolution, and, most important, improved diagnostic performance. With its capacity to quantify rest-peak stress left ventricular systolic function as well as coronary flow reserve, PET is superior to other methods for the detection of multivessel coronary artery disease and, potentially, for risk stratification. Coronary artery calcium scoring may be included for further risk stratification in patients with normal perfusion imaging findings. Furthermore, PET allows quantification of absolute myocardial perfusion, which also carries substantial prognostic value. Hybrid PET-computed tomography scanners allow functional evaluation of myocardial perfusion combined with anatomic characterization of the epicardial coronary arteries, thereby offering great potential for both diagnosis and management. Additional studies to further validate the prognostic value and cost effectiveness of PET are warranted. Harrison Phillips Jersey

PMID: 21918042

Posted in Nuclear Imaging and tagged , , , , , , .

One Comment

  1. This month, Radiographics published a fantastic series on cardiac PET/CT. Like all articles in this journal, the explanations are detailed and the concepts beautifully illustrated.

    The other articles in this series are:

    Complementary Value of Cardiac FDG PET and CT for the Characterization of Atherosclerotic Disease.
    Stolzmann P, Subramanian S, Abdelbaky A, Maurovich-Horvat P, Scheffel H, Tawakol A, Hoffmann U.
    Radiographics. 2011 Sep-Oct;31(5):1255-69.

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