Coronary Computed Tomography Angiography Versus Radionuclide Myocardial Perfusion Imaging in Patients With Chest Pain Admitted to Telemetry: A Randomized, Controlled Trial

OBJECTIVES: Coronary computed tomography angiography (CCTA) plays an expanding role in the management of symptomatic patients suspected of having coronary artery disease. Prospective intermediate-term outcomes are lacking. The objective was to compare CCTA with conventional noninvasive testing.

METHODS: This is a randomized, controlled comparative effectiveness trial. Telemetry-monitored wards of an inner-city medical center. 400 patients with acute chest pain (mean age, 57 years); 63% women; 54% Hispanic, and 37% African-American; low socioeconomic status. CCTA or radionuclide stress myocardial perfusion imaging (MPI). The primary outcome was cardiac catheterization not leading to revascularization within 1 year. Secondary outcomes included length of stay, resource utilization, and patient experience. Safety outcomes included death, major cardiovascular events, and radiation exposure.

RESULTS: Thirty (15%) patients who had CCTA and 32 (16%) who had MPI underwent cardiac catheterization within 1 year. Fifteen (7.5%) and 20 (10%) of these patients, respectively, did not undergo revascularization (difference, -2.5 percentage points [95% CI, -8.6 to 3.5 percentage points]; hazard ratio, 0.77 [CI, 0.40 to 1.49]; P  = 0.44). Median length of stay was 28.9 hours for the CCTA group and 30.4 hours for the MPI group (P = 0.057). Median follow-up duration was 40.4 months. For the CCTA and MPI groups, the incidence of death (0.5% versus 3%; P = 0.12), nonfatal cardiovascular events (4.5% versus 4.5%), rehospitalization (43% versus 49%), emergency department visit (63% versus 58%), and outpatient cardiology visit (23% versus 21%) did not differ. Long-term, all-cause radiation exposure was lower for the CCTA group (24 vs 29 mSv; P < 0.001). More patients in the CCTA group graded their experience favorably (P = 0.001) and would undergo the examination again (P = 0.003). This was a single-site study, and the primary outcome depended on clinical management decisions.

CONCLUSIONS: The CCTA and MPI groups did not significantly differ in outcomes or resource utilization over 40 months. Compared with MPI, CCTA was associated with less radiation exposure and with a more positive patient experience. Kareem Hunt Jersey

PMID: 26052677

Posted in Computed Tomography, Nuclear Imaging and tagged , , , , .

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